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Chapter 1 - Organization of Immunological Synapses and Kinapses
Marco Fritzsche and Michael L. Dustin
Pages 1-37 - Book chapterAbstract only
Chapter 2 - Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors
Shinji Ikemizu and Simon J. Davis
Pages 39-80 - Book chapterAbstract only
Chapter 3 - Synthetic Antibody Engineering: Concepts and Applications
Jonathan R. Lai, Gang Chen and Sachdev S. Sidhu
Pages 81-100 - Book chapterAbstract only
Chapter 4 - Natural Killer Cell Receptors
Sneha Rangarajan and Roy A. Mariuzza
Pages 101-125 - Book chapterAbstract only
Chapter 5 - Structure-Function in Antibodies to Double-Stranded DNA
Yumin Xia, Ertan Eryilmaz, ... Chaim Putterman
Pages 127-144 - Book chapterAbstract only
Chapter 6 - The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure
Anthony Bowen and Arturo Casadevall
Pages 145-170 - Book chapterNo access
Index
Pages 171-175
About the book
Description
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.
Key Features
- Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
- Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
- Features a collaborative editorial effort, involving clinical immunologists and structural biologists
- Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
- Gives interested parties a bridge to learn about computer modeling and structure based design principles
- Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
- Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
- Features a collaborative editorial effort, involving clinical immunologists and structural biologists
- Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
- Gives interested parties a bridge to learn about computer modeling and structure based design principles
Details
ISBN
978-0-12-803369-2
Language
English
Published
2018
Copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
Imprint
Academic Press