Cover for Structural Biology in Immunology

Structural Biology in Immunology

Structure and Function of Novel Molecules of Immunologic Importance

Book2018

Edited by:

Chaim Putterman, David Cowburn and Steven Almo

Structural Biology in Immunology

Structure and Function of Novel Molecules of Immunologic Importance

Book2018

 

Cover for Structural Biology in Immunology

Edited by:

Chaim Putterman, David Cowburn and Steven Almo

About the book

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Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in no ... read full description

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  2. Book chapterAbstract only

    Chapter 1 - Organization of Immunological Synapses and Kinapses

    Marco Fritzsche and Michael L. Dustin

    Pages 1-37

  3. Book chapterAbstract only

    Chapter 2 - Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors

    Shinji Ikemizu and Simon J. Davis

    Pages 39-80

  4. Book chapterAbstract only

    Chapter 3 - Synthetic Antibody Engineering: Concepts and Applications

    Jonathan R. Lai, Gang Chen and Sachdev S. Sidhu

    Pages 81-100

  5. Book chapterAbstract only

    Chapter 4 - Natural Killer Cell Receptors

    Sneha Rangarajan and Roy A. Mariuzza

    Pages 101-125

  6. Book chapterAbstract only

    Chapter 5 - Structure-Function in Antibodies to Double-Stranded DNA

    Yumin Xia, Ertan Eryilmaz, ... Chaim Putterman

    Pages 127-144

  7. Book chapterAbstract only

    Chapter 6 - The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure

    Anthony Bowen and Arturo Casadevall

    Pages 145-170

  8. Book chapterNo access

    Index

    Pages 171-175

About the book

Description

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.

Key Features

  • Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
  • Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
  • Features a collaborative editorial effort, involving clinical immunologists and structural biologists
  • Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
  • Gives interested parties a bridge to learn about computer modeling and structure based design principles
  • Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules
  • Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship
  • Features a collaborative editorial effort, involving clinical immunologists and structural biologists
  • Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology
  • Gives interested parties a bridge to learn about computer modeling and structure based design principles

Details

ISBN

978-0-12-803369-2

Language

English

Published

2018

Copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Imprint

Academic Press

Editors

Chaim Putterman

David Cowburn

Steven Almo